GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4660306 | 1 | rs6429567 | chr1:45956700 | CCDC163P | chr1:45960581-45965646:- | -1.11 | -31.32 | 6.93E-118 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6429567 | chr1:45956700 | MUTYH | chr1:45794915-45806142:- | 0.22 | 5.12 | 4.48E-7 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6429567 | chr1:45956700 | PRDX1 | chr1:45976708-45987609:- | -0.4 | -10.18 | 3.59E-22 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6429569 | chr1:46001330 | CCDC163P | chr1:45960581-45965646:- | -1 | -26.32 | 5.01E-95 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6429569 | chr1:46001330 | MUTYH | chr1:45794915-45806142:- | 0.2 | 4.8 | 2.11E-6 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6429569 | chr1:46001330 | PRDX1 | chr1:45976708-45987609:- | -0.37 | -9.47 | 1.27E-19 | Homocysteine levels |
| THCA | cis | rs2275426 | 1 | rs6429582 | chr1:46321843 | CCDC163P | chr1:45960581-45965646:- | 0.48 | 9.32 | 4.43E-19 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6429582 | chr1:46321843 | GPBP1L1 | chr1:46092978-46152302:- | -0.16 | -4.14 | 4.05E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6429582 | chr1:46321843 | MMACHC | chr1:45965856-45976737:+ | 0.18 | 4.05 | 6.07E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6429582 | chr1:46321843 | MUTYH | chr1:45794915-45806142:- | -0.29 | -7.95 | 1.35E-14 | Body mass index |
| THCA | cis | rs2786111 | 1 | rs643025 | chr1:197298860 | CFHR3 | chr1:196743930-196762872:+ | -0.25 | -5.2 | 2.97E-7 | Lupus nephritis in systemic lupus erythematosus |
| THCA | cis | rs6430585 | 1 | rs6430585 | chr2:136506927 | DARS | chr2:136664254-136743222:- | -0.34 | -6.27 | 8.2E-10 | Corneal structure |
| THCA | cis | rs13014235 | 1 | rs6435079 | chr2:202200331 | ALS2CR12 | chr2:202153148-202222101:- | -0.37 | -7.29 | 1.28E-12 | Basal cell carcinoma |
| THCA | cis | rs13014235 | 1 | rs6435079 | chr2:202200331 | PPIL3 | chr2:201735680-201753999:- | -0.22 | -4.55 | 6.84E-6 | Basal cell carcinoma |
| THCA | cis | rs13014235 | 1 | rs6435081 | chr2:202220623 | ALS2CR12 | chr2:202153148-202222101:- | -0.36 | -7.19 | 2.54E-12 | Basal cell carcinoma |